AD subjects included 372 non-Hispanic Caucasians recruited as part of ongoing studies of the genetics of AD or from treatment trials for AD at the University of Connecticut Health Center (UCHC), Farmington, CT and the VA Connecticut Healthcare Center (VA-CT), West Haven, CT. EA controls from CT (n = 507) were recruited by advertisement in the greater Hartford, CT area. Psychiatric diagnoses were made in these subjects using the Structured Clinical Interview for DSM-III-R or DSM-IV (SCID) (Spitzer and Williams 1995, First et al. 2001), or the Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA) (Pierucci-Lagha et al. 2005, 2007). All control subjects were screened using the SCID or the SSADDA to exclude individuals with an alcohol or drug use disorder or other major Axis I psychiatric disorder. All subjects provided written, informed consent to participate in study protocols that were approved by the institutional review boards at UCHC, Yale University School of Medicine, and/or VA-CT and were paid for their participation.
