The information required to answer the questions about the 13 decision points in the decision tree is available; however, it is spread over a variety of online sequence databases and analytical tools. Table 2 presents the databases and analytical tools used by FASTSNP for SNP prioritization and other functions. A traditional approach to integrating external sources is to download all the required data and programs and implement a huge data warehouse, but this often runs into maintenance difficulties because all the data must be kept up-to-date (11).