per day (CPD) in a meta-analysis of 73,853 subjects.16 Researchers have suggested that “missing heritability” is merely hidden and that additional loci can be discovered in GWAS with larger samples,30, 31 not to mention that the largest ND GWAS to date included 143,023 subjects,16 and many relevant genetic loci have been revealed with other experimental approaches, such as genome-wide linkage, hypothesis-driven candidate gene association, and targeted sequencing. Despite the fact that many non-GWAS findings have an uncertain yield or failed to be replicated, sorting out genetic loci with evidence from multiple approaches is not only essential but also more cost effective than pursuing a formidable sample size for GWAS.
