In this communication, we first review the literature on genetics studies for all smoking-related phenotypes using different approaches by highlighting the converging results from different approaches and then offer new hypotheses that have emerged across the allelic spectrum, including common and rare variants. These findings provide insights into the preliminary genetic architecture of ND, data that are essential for guiding future research. Crucially, we show that developing a genetic susceptibility map with data from various approaches is an effective means of knowledge integration, research progress evaluation, and research direction forecast.
