associations have emerged from these hypothesized genes of interest (Bosker et al., 2011; Collins, Kim, Sklar, O’Donovan, & Sullivan, 2012). Exceptions to this include variants in the alcohol dehydrogenase (ADH) gene cluster and alcohol outcomes (Gelernter et al., 2013; Thomasson et al., 1991) and nicotinic receptor genes (CHRNA5–CHRNA3–CHRNB4) for smoking outcomes (Broms et al., 2012; Tobacco and Genetics Consortium, 2010). Much of cGxE research tests genes thought to be involved in sensitivity to one’s environment. Considering our poor record of selecting genes with effects on complex behavioral outcomes, it may be overly optimistic to think we will be better at guessing genes involved in environmental sensitivity.
