Gene-Environment Interplay: Where We Are, Where We Are Going.
- Authors
- Salvatore, Jessica E; Dick, Danielle M
- Year
- 2015
- Journal
- Journal of marriage and the family
- PMID
- 25838604
- DOI
- 10.1111/jomf.12164
- PMCID
- PMC4378262
The idea that both genetic and environmental influences contribute to behavioral outcomes is widely accepted. However, the practice of examining candidate Gene × Environment interaction (cGxE) is controversial. In this article, we summarize some of the key issues involved in cGxE research and provide recommendations for work in this area. Highlighted challenges include the selection of the gene, the development of the cGxE hypothesis, and the coding of the genotype. To address these challenges and gain confidence in cGxE findings, we recommend using empirical data to select and code genes/variants, using theory to develop cGxE hypotheses and a rigorous and transparent approach to hypothesis testing. Family researchers have much to offer to the study of Gene × Environment research in view of their process-oriented theories that are grounded in decades of nuanced measurement of the environment; implementing these best practices will help deliver on that promise.
An Illustration of the Difficulty in Determining Whether a Genetic Variant Confers Differential Susceptibility, Using the Hypothetical Example of Internalizing Symptoms as a Function of Interparental Conflict and a Single Nucleotide Polymorphism.Note. In the low-risk sample (far right of the x-axis), the range of interparental conflict is restricted relative to the high-risk sample. Accordingly, in a low-risk sample we observe a fan-shaped interaction effect, which is consistent with a diathesis–stress model of cGxE. In a high-risk sample, where there is potentially a greater range of interparental conflict, we observe a crossover interaction effect, which is consistent with a differential susceptibility model of cGxE.
No entities extracted from this document yet.
No uploaded files.
No papers in this knowledge base cite this source.
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A person-centered data analytic approach to dopaminergic polygenic moderation of child maltreatment exposure. | Handley ED et al. | — | 2023 | → |
| Beyond orchids and dandelions: Susceptibility to environmental influences is not bimodal. | Zhang X et al. | — | 2023 | → |
| The collaborative study on the genetics of alcoholism: Sample and clinical data. | Dick DM et al. | — | 2023 | → |
| Three phases of Gene × Environment interaction research: Theoretical assumptions underlying gene selection. | Zhang X et al. | — | 2022 | → |
| Gene-environment interaction: Oxytocin receptor (OXTR) polymorphisms and parenting style as potential predictors for depressive symptoms. | Keijser R et al. | — | 2021 | → |
| Sometimes It's Good to be Short: The Serotonin Transporter Gene, Positive Parenting, and Adolescent Depression. | Little K et al. | — | 2019 | → |
| Associations between alcohol dehydrogenase genes and alcohol use across early and middle adolescence: Moderation × Preventive intervention. | Cleveland HH et al. | — | 2018 | → |
| What changes when? A reply to Beauchaine and Slep. | Weeland J et al. | — | 2018 | → |
| Extending Previous cG×I Findings on 5-HTTLPR's Moderation of Intervention Effects on Adolescent Substance Misuse Initiation. | Schlomer GL et al. | — | 2017 | → |
| Genetic and psychosocial predictors of alcohol use trajectories among disaster-exposed adolescents. | Bountress K et al. | — | 2017 | → |
| Parent and peer influences on emerging adult substance use disorder: A genetically informed study. | Bountress K et al. | — | 2017 | → |
| Looking Forward in Candidate Gene Research: Concerns and Suggestions. | Schlomer GL et al. | — | 2015 | → |
| Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms. | Weeland J et al. | — | 2015 | → |