Family researchers have much to offer to the study of GxE in view of their process-oriented theories that are grounded in decades of nuanced measurement of the environment. Schlomer et al.’s article, which draws on the emotional security and cognitive appraisal literatures to examine pathways from interparental relationship factors to adolescent internalizing, is an excellent example of this. However, to fully reach this promise, careful attention must be paid to the G that gets integrated into studies of GxE, and the methods used to study GxE. Increased awareness and attention to these issues among researchers, journal reviewers, and journal editors will—we hope—increase the quality of cGxE work and the potential of biopsychosocial approaches to inform our understanding of family processes.