Aliev, Bucholz, et al., 2014; Salvatore, Aliev, Edwards, et al., 2014). However, we note that using polygenic risk scores in tests of GxE assumes that most of the genes of interest for that trait are moderated in the same way. This may be more reasonable for some hypotheses (e.g., in substance use, where restrictive environments that limit one’s access to alcohol would reduce the likelihood of expressing a predisposition toward substance use; Dick, Pagan, et al., 2007) than others (e.g., GxE analyses of stressful life events may be more limited to genes involved in stress response).
