Common disorders are quantitative traits.
paper
Cited
Public
Unavailable
- Authors
- Plomin, Robert; Haworth, Claire M A; Davis, Oliver S P
- Year
- 2009
- Journal
- Nature reviews. Genetics
- PMID
- 19859063
- DOI
- 10.1038/nrg2670
After drifting apart for 100 years, the two worlds of genetics - quantitative genetics and molecular genetics - are finally coming together in genome-wide association (GWA) research, which shows that the heritability of complex traits and common disorders is due to multiple genes of small effect size. We highlight a polygenic framework, supported by recent GWA research, in which qualitative disorders can be interpreted simply as being the extremes of quantitative dimensions. Research that focuses on quantitative traits - including the low and high ends of normal distributions - could have far-reaching implications for the diagnosis, treatment and prevention of the problematic extremes of these traits.
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|---|---|---|---|---|
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| Active night-time tweeting is associated with meaningfully lower mental wellbeing in a UK birth cohort study. | Joinson D et al. | β | 2025 | β |
| Autistic traits relate to speed/accuracy trade-off but not statistical learning and updating. | Hann F et al. | β | 2025 | β |
| Building digital histology models of transcriptional tumor programs with generative deep learning for pathology-based precision medicine. | Hieromnimon HM et al. | β | 2025 | β |
| Identification of five sleep-biopsychosocial profiles with specific neural signatures linking sleep variability with health, cognition, and lifestyle factors. | Perrault AA et al. | β | 2025 | β |
| Intact ultrafast memory consolidation in adults with autism and neurotypicals with autism traits. | Nagy CA et al. | β | 2025 | β |
| Internalizing Psychiatric Symptoms in People With Mosaicism for Trisomy 21. | Brown RC et al. | β | 2025 | β |
| Intolerance of Uncertainty Mediates the Relationship Between Autistic Traits and a Propensity for Deliberation. | Brosnan M et al. | β | 2025 | β |
| Non-Gaussian Liability Distribution for Depression in the General Population. | Talkkari A et al. | β | 2025 | β |
| Psychotropic Taxonomies: Constructing a Therapeutic Framework for Psychiatry. | McCutcheon RA et al. | β | 2025 | β |
| Socio-economic status is a social construct with heritable components and genetic consequences. | Abdellaoui A et al. | β | 2025 | β |
| The etiological relationship between the general factors of psychopathology and personality; a longitudinal twin study from adolescence into young adulthood. | Waaktaar T et al. | β | 2025 | β |
| What clinicians should know about the contribution of modern behavioral genetics to psychiatric problems. | Plomin R et al. | β | 2025 | β |
| A pattern of continuity from health to disease in neuropsychiatric genetic risk affecting brain morphology | CHOU C et al. | β | 2024 | β |
| Dopamine and Serotonin Transporter Genes Regulation in Highly Sensitive Individuals during Stressful Conditions: A Focus on Genetics and Epigenetics. | Bellia F et al. | β | 2024 | β |
| Effect of scanning duration and sample size on reliability in resting state fMRI dynamic causal modeling analysis. | Ma L et al. | β | 2024 | β |
| Gene expression variation underlying tissue-specific responses to copper stress in Drosophila melanogaster. | Everman ER et al. | β | 2024 | β |
| Genetic Association Studies in Host-Pathogen Interaction Analysis. | Laplana M et al. | β | 2024 | β |
| Interaction between Risk Single-Nucleotide Polymorphisms of Developmental Dyslexia and Parental Education on Reading Ability: Evidence for Differential Susceptibility Theory. | Yang Q et al. | β | 2024 | β |
| Multimodal neural correlates of childhood psychopathology. | Royer J et al. | β | 2024 | β |
| Polygenic Scores and Networks of Psychopathology Symptoms. | Piazza GG et al. | β | 2024 | β |
| R2ROC: an efficient method of comparing two or more correlated AUC from out-of-sample prediction using polygenic scores. | Momin MM et al. | β | 2024 | β |
| Scrutinizing neurodegenerative diseases: decoding the complex genetic architectures through a multi-omics lens. | CocoΘ R et al. | β | 2024 | β |
| Silence is golden, but my measures still see-why cheaper-but-noisier outcome measures in large simple trials can be more cost-effective than gold standards. | Woolf B et al. | β | 2024 | β |
| The future of neuroscience in developmental psychopathology. | Hyde LW et al. | β | 2024 | β |
| The Women4Health cohort: a unique cohort to study women-specific mechanisms of cardio-metabolic regulation. | Busonero F et al. | β | 2024 | β |
| Understanding and Treating Persecutory Delusions. | Freeman D | β | 2024 | β |
| A critical role of brain network architecture in a continuum model of autism spectrum disorders spanning from healthy individuals with genetic liability to individuals with ASD. | Khundrakpam B et al. | β | 2023 | β |
| Advancing research on early autism through an integrated risk and resilience perspective. | Stallworthy IC et al. | β | 2023 | β |
| Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults. | Su J et al. | β | 2023 | β |
| Cytosine base editors induce off-target mutations and adverse phenotypic effects in transgenic mice. | Yan N et al. | β | 2023 | β |
| Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies. | Waszczuk MA et al. | β | 2023 | β |
| Direction of dependence analysis for pre-post assessments using non-Gaussian methods: a tutorial. | RosenstrΓΆm TH et al. | β | 2023 | β |
| DNA methylation at birth and fine motor ability in childhood: an epigenome-wide association study with replication. | Serdarevic F et al. | β | 2023 | β |
| Gene-environment correlations and genetic confounding underlying the association between media use and mental health. | Ayorech Z et al. | β | 2023 | β |
| Genetic Influences on Cognitive Dysfunction in Schizophrenia. | Greenwood TA | β | 2023 | β |
| Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders. | Alex AM et al. | β | 2023 | β |
| Genetic profile for dopamine signaling predicts brain functional reactivity to repetitive transcranial magnetic stimulation. | Hong H et al. | β | 2023 | β |
| Machine learning-based marker for coronary artery disease: derivation and validation in two longitudinal cohorts. | Forrest IS et al. | β | 2023 | β |
| Maternal depression and the polygenic p factor: A family perspective on direct and indirect effects. | Ayorech Z et al. | β | 2023 | β |
| Measurement Invariant but Non-Normal Treatment Responses in Guided Internet Psychotherapies for Depressive and Generalized Anxiety Disorders. | RosenstrΓΆm TH et al. | β | 2023 | β |
| Mechanisms of cognitive disinhibition explain individual differences in adult attention deficit hyperactivity disorder traits. | Tiego J et al. | β | 2023 | β |
| Mendelian inheritance revisited: dominance and recessiveness in medical genetics. | Zschocke J et al. | β | 2023 | β |
| Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort. | He Q et al. | β | 2023 | β |
| New historical and philosophical perspectives on quantitative genetics. | Serpico D et al. | β | 2023 | β |
| Pathophysiological Effects of Contemporary Lifestyle on Evolutionary-Conserved Survival Mechanisms in Polycystic Ovary Syndrome. | Parker J | β | 2023 | β |
| Precision behavioral phenotyping as a strategy for uncovering the biological correlates of psychopathology. | Tiego J et al. | β | 2023 | β |
| Significance tests for R<sup>2</sup> of out-of-sample prediction using polygenic scores. | Momin MM et al. | β | 2023 | β |
| Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH). | Boberg J et al. | β | 2023 | β |
| Association between genetic and socioenvironmental risk for schizophrenia during upbringing in a UK longitudinal cohort. | Newbury JB et al. | β | 2022 | β |
| Association of cumulative early medical factors with autism and autistic symptoms in a population-based twin sample. | Carlsson T et al. | β | 2022 | β |
| Challenges and future directions for studying effects of host genetics on the gut microbiome. | Sanna S et al. | β | 2022 | β |
| Commentary: The origins of intellectual disability. | Plomin R | β | 2022 | β |
| Editorial: Looking for a culprit: The role of environmental co-factors in complex neuropsychiatric disorders. | Manchia M et al. | β | 2022 | β |
| Examining social genetic effects on educational attainment via parental educational attainment, income, and parenting. | Su J et al. | β | 2022 | β |
| Genetic risk of AUDs and childhood impulsivity: Examining the role of parenting and family environment. | Su J et al. | β | 2022 | β |
| Genetics in the ADHD Clinic: How Can Genetic Testing Support the Current Clinical Practice? | Balogh L et al. | β | 2022 | β |
| Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities. | Mallard TT et al. | β | 2022 | β |
| Neonatal amygdala resting-state functional connectivity and socio-emotional development in very preterm children. | Kanel D et al. | β | 2022 | β |
| Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment. | Parker J et al. | β | 2022 | β |
| Postnatal maternal depressive symptoms and behavioural outcomes in term-born and preterm-born toddlers: a longitudinal UK community cohort study. | Kleine I et al. | β | 2022 | β |
| Racial Discrimination and Alcohol Problems: Examining Interactions with Genetic Risk and Impulsivity among African American Young Adults. | Su J et al. | β | 2022 | β |
| Right Anterior Theta Hypersynchrony as a Quantitative Measure Associated with Autistic Traits and K-Cl Cotransporter KCC2 Polymorphism. | Aykan S et al. | β | 2022 | β |
| Risk factors relate to the variability of health outcomes as well as the mean: A GAMLSS tutorial. | Bann D et al. | β | 2022 | β |
| Seven reasons why binary diagnostic categories should be replaced with empirically sounder and less stigmatizing dimensions. | Lahey BB et al. | β | 2022 | β |
| The Hierarchical Taxonomy of Psychopathology (HiTOP) in psychiatric practice and research. | Kotov R et al. | β | 2022 | β |
| The next 10Β years of behavioural genomic research. | Plomin R | β | 2022 | β |
| [The promise of omics in the precision medicine era]. | Tebani A et al. | β | 2022 | β |
| Association of etiological factors across the extreme end and continuous variation in disordered eating in female Swedish twins. | Dinkler L et al. | β | 2021 | β |
| Childhood adversity is linked to adult health among African Americans via adolescent weight gain and effects are genetically moderated. | Beach SRH et al. | β | 2021 | β |
| Clinical validation of the parent-report Toronto Obsessive-Compulsive Scale (TOCS): A pediatric open-source rating scale. | Lambe LJ et al. | β | 2021 | β |
| Cross-Diagnosis Structural Correlates of Autistic-Like Social Communication Differences. | Kushki A et al. | β | 2021 | β |
| Dopaminergic Genetic Variation in Young Adolescents: Associations with Sensation-Seeking. | Sapuram VR et al. | β | 2021 | β |
| Early life course processes leading to educational and economic attainment in young adulthood: Contributions of early socioeconomic adversity and education polygenic score. | Wickrama KAS et al. | β | 2021 | β |
| Genetic Association Studies of Age-Related Traits: New Perspectives. | Kulminski AM | β | 2021 | β |
| Genetic contributions to anxiety disorders: where we are and where we are heading. | Ask H et al. | β | 2021 | β |
| Genetics on the neurodiversity spectrum: Genetic, phenotypic and endophenotypic continua in autism and ADHD. | Koi P | β | 2021 | β |
| In Search of Cognitive Promotive and Protective Factors for Word Reading. | Slomowitz RF et al. | β | 2021 | β |
| Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction. | Demange PA et al. | β | 2021 | β |
| Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders. | Lee PH et al. | β | 2021 | β |
| Polygenic Scores for ADHD: A Meta-Analysis. | Li JJ et al. | β | 2021 | β |
| Populations, Traits, and Their Spatial Structure in Humans. | Sohail M et al. | β | 2021 | β |
| Predicting anthropometric and metabolic traits with a genetic risk score for obesity in a sample of Pakistanis. | Rana S et al. | β | 2021 | β |
| Protective association of the Ξ΅2/Ξ΅3 heterozygote with Alzheimer's disease is strengthened by TOMM40-APOE variants in men. | Kulminski AM et al. | β | 2021 | β |
| Quantitative disease risk scores from EHR with applications to clinical risk stratification and genetic studies. | Xu D et al. | β | 2021 | β |
| Resting state alpha oscillatory activity is a valid and reliable marker of schizotypy. | Trajkovic J et al. | β | 2021 | β |
| The DSM-5 introduction of the Social (Pragmatic) Communication Disorder as a new mental disorder: a philosophical review. | Amoretti MC et al. | β | 2021 | β |
| The influence of regression models on genome-wide association studies of alcohol dependence: a comparison of binary and quantitative analyses. | Li W et al. | β | 2021 | β |
| The positive end of the polygenic score distribution for ADHD: a low risk or a protective factor? | Li JJ | β | 2021 | β |
| The revised Green <i>et al.</i>, Paranoid Thoughts Scale (R-GPTS): psychometric properties, severity ranges, and clinical cut-offs. | Freeman D et al. | β | 2021 | β |
| The utility of hierarchical models of psychopathology in genetics and biomarker research. | Waszczuk MA | β | 2021 | β |
| Why do depression, conduct, and hyperactivity symptoms co-occur across adolescence? The role of stable and dynamic genetic and environmental influences. | Waszczuk MA et al. | β | 2021 | β |
| A major role for common genetic variation in anxiety disorders. | Purves KL et al. | β | 2020 | β |
| A Polygenic and Phenotypic Risk Prediction for Polycystic Ovary Syndrome Evaluated by Phenome-Wide Association Studies. | Joo YY et al. | β | 2020 | β |
| Associations between aversive learning processes and transdiagnostic psychiatric symptoms in a general population sample. | Wise T et al. | β | 2020 | β |
| Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease. | Hollander JA et al. | β | 2020 | β |
| Do Genes Associated with Dyslexia of Chinese Characters Evolve Neutrally? | Nishiyama KV et al. | β | 2020 | β |
| Genetic feedback for psychiatric conditions: Where are we now and where are we going. | Driver MN et al. | β | 2020 | β |
| Genome-Wide Polygenic Score and the Risk of Ischemic Stroke in a Prospective Cohort: The Hisayama Study. | Hachiya T et al. | β | 2020 | β |
| Heritability of overlapping impulsivity and compulsivity dimensional phenotypes. | Tiego J et al. | β | 2020 | β |
| Neural correlates of polygenic risk score for autism spectrum disorders in general population. | Khundrakpam B et al. | β | 2020 | β |
| Obsessive-compulsive disorder and attention-deficit/hyperactivity disorder: distinct associations with DNA methylation and genetic variation. | Goodman SJ et al. | β | 2020 | β |
| Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project. | Saito S et al. | β | 2020 | β |
| PheMap: a multi-resource knowledge base for high-throughput phenotyping within electronic health records. | Zheng NS et al. | β | 2020 | β |
| Polygenic risk scores and the prediction of common diseases. | Ala-Korpela M et al. | β | 2020 | β |
| Redefining phenotypes to advance psychiatric genetics: Implications from hierarchical taxonomy of psychopathology. | Waszczuk MA et al. | β | 2020 | β |
| Subclinical eating disorder traits are correlated with cortical thickness in regions associated with food reward and perception. | Wallace GL et al. | β | 2020 | β |
| The Genetic Architecture of High Bone Mass. | Gregson CL et al. | β | 2020 | β |
| The p factor: genetic analyses support a general dimension of psychopathology in childhood and adolescence. | Allegrini AG et al. | β | 2020 | β |
| Twin studies of the covariation of pain with depression and anxiety: A systematic review and re-evaluation of critical needs. | Khan WU et al. | β | 2020 | β |
| Type 2 diabetes mellitus: pathogenesis and genetic diagnosis. | Himanshu D et al. | β | 2020 | β |
| Are there shared neural correlates between dyslexia and ADHD? A meta-analysis of voxel-based morphometry studies. | McGrath LM et al. | β | 2019 | β |
| Artificial Intelligence for Cardiac Imaging-Genetics Research. | de Marvao A et al. | β | 2019 | β |
| Association of Genetic Risk Factors for Psychiatric Disorders and Traits of These Disorders in a Swedish Population Twin Sample. | Taylor MJ et al. | β | 2019 | β |
| Cumulative risk and protection effect of serotonergic genes on male antisocial behaviour: results from a prospective cohort assessed in adolescence and early adulthood. | Langevin S et al. | β | 2019 | β |
| Delineating and validating higher-order dimensions of psychopathology in the Adolescent Brain Cognitive Development (ABCD) study. | Michelini G et al. | β | 2019 | β |
| Etiological influences on continuity and co-occurrence of eating disorders symptoms across adolescence and emerging adulthood. | Waszczuk MA et al. | β | 2019 | β |
| Evaluation of the Genetic Variance of Alzheimer's Disease Explained by the Disease-Associated Chromosomal Regions. | Nazarian A et al. | β | 2019 | β |
| Examining overlap and homogeneity in ASD, ADHD, and OCD: a data-driven, diagnosis-agnostic approach. | Kushki A et al. | β | 2019 | β |
| Functional Connectivity of Corticostriatal Circuitry and Psychosis-like Experiences in the General Community. | Sabaroedin K et al. | β | 2019 | β |
| Genes, Roommates, and Residence Halls: A Multidimensional Study of the Role of Peer Drinking on College Students' Alcohol Use. | Smith RL et al. | β | 2019 | β |
| Genetic and environmental contribution to the overlap between ADHD and ASD trait dimensions in young adults: a twin study. | Ghirardi L et al. | β | 2019 | β |
| Genetic and Environmental Links between : General Factors of Psychopathology and Cognitive Ability in Early Childhood. | Grotzinger AD et al. | β | 2019 | β |
| Heritability and individuality of the plasma sodium concentration: a twin study in the United States veteran population. | Timmons AK et al. | β | 2019 | β |
| Identification of microsatellite markers and their application in yellow catfish (<i>Pseudobagrus fulvidraco</i> Richardson, 1846) population genetics of Korea. | Yu JN et al. | β | 2019 | β |
| Is There a Relationship Between Cyber-Dependent Crime, Autistic-Like Traits and Autism? | Payne KL et al. | β | 2019 | β |
| Modulation of anterior cingulate cortex reward and penalty signalling in medication-naive young-adult subjects with depressive symptoms following acute dose lurasidone. | Wolke SA et al. | β | 2019 | β |
| Numero: a statistical framework to define multivariable subgroups in complex population-based datasets. | Gao S et al. | β | 2019 | β |
| Phenotypic Annotation: Using Polygenic Scores to Translate Discoveries From Genome-Wide Association Studies From the Top Down. | Belsky DW et al. | β | 2019 | β |
| Pleiotropic Meta-Analysis of Age-Related Phenotypes Addressing Evolutionary Uncertainty in Their Molecular Mechanisms. | Kulminski AM et al. | β | 2019 | β |
| Polygenic risk for alcohol misuse is moderated by romantic partnerships. | Barr PB et al. | β | 2019 | β |
| Predicting Polygenic Risk of Psychiatric Disorders. | Martin AR et al. | β | 2019 | β |
| Psychiatric genetics and the structure of psychopathology. | Smoller JW et al. | β | 2019 | β |
| Quantifying the Optimal Structure of the Autism Phenotype: A Comprehensive Comparison of Dimensional, Categorical, and Hybrid Models. | Kim H et al. | β | 2019 | β |
| SWAN scale for ADHD trait-based genetic research: a validity and polygenic risk study. | Burton CL et al. | β | 2019 | β |
| Syllogistic reasoning reveals reduced bias in people with higher autistic-like traits from the general population. | Lewton M et al. | β | 2019 | β |
| The alteration landscape of the cerebral cortex. | Cauda F et al. | β | 2019 | β |
| The Family Check-up Intervention Moderates Polygenic Influences on Long-Term Alcohol Outcomes: Results from a Randomized Intervention Trial. | Kuo SI et al. | β | 2019 | β |
| The Search for Clinically Useful Biomarkers of Complex Disease: A Data Analysis Perspective. | Considine EC | β | 2019 | β |
| Transcriptome profiling of four candidate milk genes in milk and tissue samples of temperate and tropical cattle. | Morenikeji OB et al. | β | 2019 | β |
| 'Twisting the lion's tail': Manipulationist tests of causation for psychological mechanisms in the occurrence of delusions and hallucinations. | Brown P et al. | β | 2019 | β |
| Understanding human DNA variants affecting pre-mRNA splicing in the NGS era. | Dufner-Almeida LG et al. | β | 2019 | β |
| Using DNA to predict educational trajectories in early adulthood. | Ayorech Z et al. | β | 2019 | β |
| Validating psychosocial pathways of risk between neuroticism and late life depression using a polygenic score approach. | Li JJ et al. | β | 2019 | β |
| A genome-wide association study for extremely high intelligence. | Zabaneh D et al. | β | 2018 | β |
| A Key Characteristic of Sex Differences in the Developing Brain: Greater Variability in Brain Structure of Boys than Girls. | Wierenga LM et al. | β | 2018 | β |
| Alcohol Intoxication Moderates the Association between a Polygenic Risk Score and Unprovoked Intimate Partner Aggression. | Christ CC et al. | β | 2018 | β |
| Alexithymia and autistic traits as possible predictors for traits related to depression, anxiety, and stress: A multivariate statistical approach. | Fietz J et al. | β | 2018 | β |
| A Medal in the Olympics Runs in the Family: A Cohort Study of Performance Heritability in the Games History. | Antero J et al. | β | 2018 | β |
| A prediction model of working memory across health and psychiatric disease using whole-brain functional connectivity. | Yamashita M et al. | β | 2018 | β |
| ASD and schizophrenia show distinct developmental profiles in common genetic overlap with population-based social communication difficulties. | St Pourcain B et al. | β | 2018 | β |
| A Simple Test Identifies Selection on Complex Traits. | Beissinger T et al. | β | 2018 | β |
| Assessing the evidence for shared genetic risks across psychiatric disorders and traits. | Martin J et al. | β | 2018 | β |
| Assessment of genotyping tools applied in genetic susceptibility studies of periodontal disease: A systematic review. | de Coo A et al. | β | 2018 | β |
| Autism: a transdiagnostic, dimensional, construct of reasoning? | Aggernaes B | β | 2018 | β |
| Brain donation at autopsy: clinical characterization and toxicologic analyses. | Mighdoll MI et al. | β | 2018 | β |
| Does education attenuate the genetic risk of obesity? Evidence from U.K. Twins. | Amin V et al. | β | 2018 | β |
| Does perinatal exposure to exogenous oxytocin influence child behavioural problems and autistic-like behaviours to 20Β years of age? | Guastella AJ et al. | β | 2018 | β |
| Do High and Low Extremes of ADHD and ASD Trait Continua Represent Maladaptive Behavioral and Cognitive Outcomes? A Population-Based Study. | Greven CU et al. | β | 2018 | β |
| Emotion regulation difficulties in traumatized youth: a meta-analysis and conceptual review. | Villalta L et al. | β | 2018 | β |
| Evaluating the genetic susceptibility to peer reported bullying behaviors. | Musci RJ et al. | β | 2018 | β |
| Examining interactions between genetic risk for alcohol problems, peer deviance, and interpersonal traumatic events on trajectories of alcohol use disorder symptoms among African American college students. | Su J et al. | β | 2018 | β |
| Examining the intertwined development of prosocial skills and ASD symptoms in adolescence. | Oerlemans AM et al. | β | 2018 | β |
| Frequency and phenotype consequence of APOC3 rare variants in patients with very low triglyceride levels. | Crawford DC et al. | β | 2018 | β |
| From lipid locus to drug target through human genomics. | van der Laan SW et al. | β | 2018 | β |
| From positive psychology to psychopathology: the continuum of attention-deficit hyperactivity disorder. | Greven CU et al. | β | 2018 | β |
| Gene-environment interaction and psychiatric disorders: Review and future directions. | Assary E et al. | β | 2018 | β |
| Genetic Modifiers in Neurodegeneration. | Jain N et al. | β | 2018 | β |
| Genetic Risks for Chronic Conditions: Implications for Long-term Wellbeing. | Wehby GL et al. | β | 2018 | β |
| Genetic variants in mRNA untranslated regions. | Steri M et al. | β | 2018 | β |
| Genome-wide association studies in Crohn's disease: Past, present and future. | Verstockt B et al. | β | 2018 | β |
| Genome-wide association study of depressive symptoms in the Hispanic Community Health Study/Study of Latinos. | Dunn EC et al. | β | 2018 | β |
| Genome-wide association study of extreme high bone mass: Contribution of common genetic variation to extreme BMD phenotypes and potential novel BMD-associated genes. | Gregson CL et al. | β | 2018 | β |
| Genomic and Expression Analyses Identify a Disease-Modifying Variant for Fibrostenotic Crohn's Disease. | Visschedijk MC et al. | β | 2018 | β |
| Genotype scores predict drug efficacy in subtypes of female sexual interest/arousal disorder: A double-blind, randomized, placebo-controlled cross-over trial. | Tuiten A et al. | β | 2018 | β |
| Heritability of obsessive-compulsive trait dimensions in youth from the general population. | Burton CL et al. | β | 2018 | β |
| IBD in 2017: Development of therapy for and prediction of IBD - getting personal. | Atreya R et al. | β | 2018 | β |
| Mitochondrial polymorphisms contribute to aging phenotypes in MNX mouse models. | Vivian CJ et al. | β | 2018 | β |
| Modeling the quantitative nature of neurodevelopmental disorders using Collaborative Cross mice. | Molenhuis RT et al. | β | 2018 | β |
| Models of Schizotypy: The Importance of Conceptual Clarity. | Grant P et al. | β | 2018 | β |
| Polygenic Score Γ Intervention Moderation: an Application of Discrete-Time Survival Analysis to Model the Timing of First Marijuana Use Among Urban Youth. | Musci RJ et al. | β | 2018 | β |
| Practitioner Review: Definition, recognition, and treatment challenges of irritability in young people. | Stringaris A et al. | β | 2018 | β |
| Predicting loneliness with polygenic scores of social, psychological and psychiatric traits. | Abdellaoui A et al. | β | 2018 | β |
| Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co-occurring traits. | Knoll AT et al. | β | 2018 | β |
| Rigor and reproducibility in genetic research on eating disorders. | HΓΌbel C et al. | β | 2018 | β |
| Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes. | Kulminski AM et al. | β | 2018 | β |
| The Home Observation Measure of the Environment is associated with symptoms of ADHD and oppositionality in a CAMHS sample. | Lai WW et al. | β | 2018 | β |
| The new genetics of intelligence. | Plomin R et al. | β | 2018 | β |
| Visual search and autism symptoms: What young children search for and co-occurring ADHD matter. | Doherty BR et al. | β | 2018 | β |
| Are schizophrenia, autistic, and obsessive spectrum disorders dissociable on the basis of neuroimaging morphological findings?: A voxel-based meta-analysis. | Cauda F et al. | β | 2017 | β |
| A review of the role of serotonin system genes in obsessive-compulsive disorder. | Sinopoli VM et al. | β | 2017 | β |
| Autism and emotional face-viewing. | Γ sberg Johnels J et al. | β | 2017 | β |
| Autoimmune aspects of psoriasis: Heritability and autoantigens. | Prinz JC | β | 2017 | β |
| Differences in bone structure and unloading-induced bone loss between C57BL/6N and C57BL/6J mice. | Sankaran JS et al. | β | 2017 | β |
| Genetic and environmental contributions to the association between ADHD and affective problems in early childhood-A Swedish population-based twin study. | Rydell M et al. | β | 2017 | β |
| Genetic association studies in cardiovascular diseases: Do we have enough power? | Auer PL et al. | β | 2017 | β |
| Genetic Heterogeneity in Depressive Symptoms Following the Death of a Spouse: Polygenic Score Analysis of the U.S. Health and Retirement Study. | Domingue BW et al. | β | 2017 | β |
| Genetic rodent models of brain disorders: Perspectives on experimental approaches and therapeutic strategies. | McGraw CM et al. | β | 2017 | β |
| Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. | Lo MT et al. | β | 2017 | β |
| Genome-Wide Associations Related to Hepatic Histology in Nonalcoholic Fatty Liver Disease in Hispanic Boys. | Wattacheril J et al. | β | 2017 | β |
| Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease. | Lee JC et al. | β | 2017 | β |
| Genome-wide association study of generalized anxiety symptoms in the Hispanic Community Health Study/Study of Latinos. | Dunn EC et al. | β | 2017 | β |
| Homogeneous Combinations of ASD-ADHD Traits and Their Cognitive and Behavioral Correlates in a Population-Based Sample. | van der Meer JMJ et al. | β | 2017 | β |
| Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential. | Bogdan R et al. | β | 2017 | β |
| Mixed Model Association with Family-Biased Case-Control Ascertainment. | Hayeck TJ et al. | β | 2017 | β |
| Negative affect is unrelated to fluctuations in hormone levels across the menstrual cycle: Evidence from a multisite observational study across two successive cycles. | Hengartner MP et al. | β | 2017 | β |
| O-GlcNAcylation mediates the control of cytosolic phosphoenolpyruvate carboxykinase activity via Pgc1Ξ±. | Latorre P et al. | β | 2017 | β |
| Over-Selectivity is Related to Autism Quotient and Empathizing, But not to Systematizing. | Reed P | β | 2017 | β |
| Paternal Age Alters Social Development in Offspring. | Janecka M et al. | β | 2017 | β |
| Renal Aging: Causes and Consequences. | O'Sullivan ED et al. | β | 2017 | β |
| Reward-related ventral striatum activity links polygenic risk for attention-deficit/hyperactivity disorder to problematic alcohol use in young adulthood. | Carey CE et al. | β | 2017 | β |
| Risk and protective factors for comorbid internalizing and externalizing problems among economically disadvantaged African American youth. | Liu J et al. | β | 2017 | β |
| Roles of Response Inhibition and Gene-Environment Interplay in Pathways to Adolescents' Externalizing Problems. | Wang FL et al. | β | 2017 | β |
| Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development. | Stergiakouli E et al. | β | 2017 | β |
| Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine. | Fini ME et al. | β | 2017 | β |
| The common variants implicated in microstructural abnormality of first episode and drug-naΓ―ve patients with schizophrenia. | Ren HY et al. | β | 2017 | β |
| The developmental relationship between specific cognitive domains and grey matter in the cerebellum. | Moore DM et al. | β | 2017 | β |
| The Impact of Peer Substance Use and Polygenic Risk on Trajectories of Heavy Episodic Drinking Across Adolescence and Emerging Adulthood. | Li JJ et al. | β | 2017 | β |
| Transcriptional profiling of human femoral mesenchymal stem cells in osteoporosis and its association with adipogenesis. | Choi YJ et al. | β | 2017 | β |
| A Genetically Informed Cross-Lagged Analysis of Autistic-Like Traits and Affective Problems in Early Childhood. | Micalizzi L et al. | β | 2016 | β |
| A genome-wide analysis of putative functional and exonic variation associated with extremely high intelligence. | Spain SL et al. | β | 2016 | β |
| A longitudinal twin and sibling study of the hopelessness theory of depression in adolescence and young adulthood. | Waszczuk MA et al. | β | 2016 | β |
| An Adolescent Substance Prevention Model Blocks the Effect of CHRNA5 Genotype on Smoking During High School. | Vandenbergh DJ et al. | β | 2016 | β |
| Annual Research Review: Transdiagnostic neuroscience of child and adolescent mental disorders--differentiating decision making in attention-deficit/hyperactivity disorder, conduct disorder, depression, and anxiety. | Sonuga-Barke EJ et al. | β | 2016 | β |
| Antisocial behavior and polymorphisms in the oxytocin receptor gene: findings in two independent samples. | Hovey D et al. | β | 2016 | β |
| Anxious personality and functional efficiency of the insular-opercular network: A graph-analytic approach to resting-state fMRI. | Markett S et al. | β | 2016 | β |
| Assortative mating and differential fertility by phenotype and genotype across the 20th century. | Conley D et al. | β | 2016 | β |
| Brain connectivity in normally developing children and adolescents. | Khundrakpam BS et al. | β | 2016 | β |
| Discontinuity in the genetic and environmental causes of the intellectual disability spectrum. | Reichenberg A et al. | β | 2016 | β |
| Dopamine and serotonin genetic risk scores predicting substance and nicotine use in attention deficit/hyperactivity disorder. | Groenman AP et al. | β | 2016 | β |
| Epistasis and Pleiotropy Affect the Modularity of the Genotype-Phenotype Map of Cross-Resistance in HIV-1. | Polster R et al. | β | 2016 | β |
| Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population. | Robinson EB et al. | β | 2016 | β |
| Genetic Variants in CHIA and CHI3L1 Are Associated with the IgE Response to the Ascaris Resistance Marker ABA-1 and the Birch Pollen Allergen Bet v 1. | Acevedo N et al. | β | 2016 | β |
| Meta-analysis of genome-wide association studies of anxiety disorders. | Otowa T et al. | β | 2016 | β |
| Metabolic profiling-multitude of technologies with great research potential, but (when) will translation emerge? | Ala-Korpela M et al. | β | 2016 | β |
| Metabolomics in cardiovascular medicine: Not personalised, not diagnostic. | Ala-Korpela M | β | 2016 | β |
| New dimensions in the use of rodent behavioral tests for novel drug discovery and development. | Hoffman KL | β | 2016 | β |
| Omics-Based Strategies in Precision Medicine: Toward a Paradigm Shift in Inborn Errors of Metabolism Investigations. | Tebani A et al. | β | 2016 | β |
| Phenome-wide analysis of genome-wide polygenic scores. | Krapohl E et al. | β | 2016 | β |
| Prevalence of Sclerosing Cholangitis Detected by Magnetic Resonance Cholangiography in Patients With Long-term Inflammatory Bowel Disease. | Lunder AK et al. | β | 2016 | β |
| Quantitative Trait Loci and a Novel Genetic Candidate for Fear Learning. | Knoll AT et al. | β | 2016 | β |
| Reasoning on the Autism Spectrum: A Dual Process Theory Account. | Brosnan M et al. | β | 2016 | β |
| Reflections on the Field of Human Genetics: A Call for Increased Disease Genetics Theory. | Schrodi SJ | β | 2016 | β |
| The Bell Curve Revisited: Testing Controversial Hypotheses with Molecular Genetic Data. | Conley D et al. | β | 2016 | β |
| The Combined Effect of Common Genetic Risk Variants on Circulating Lipoproteins Is Evident in Childhood: A Longitudinal Analysis of the Cardiovascular Risk in Young Finns Study. | Buscot MJ et al. | β | 2016 | β |
| The opposite end of the attention deficit hyperactivity disorder continuum: genetic and environmental aetiologies of extremely low ADHD traits. | Greven CU et al. | β | 2016 | β |
| The stability and change of etiological influences on depression, anxiety symptoms and their co-occurrence across adolescence and young adulthood. | Waszczuk MA et al. | β | 2016 | β |
| The Status of Irritability in Psychiatry: A Conceptual and Quantitative Review. | Vidal-Ribas P et al. | β | 2016 | β |
| The Toronto Obsessive-Compulsive Scale: Psychometrics of a Dimensional Measure of Obsessive-Compulsive Traits. | Park LS et al. | β | 2016 | β |
| Top 10 Replicated Findings From Behavioral Genetics. | Plomin R et al. | β | 2016 | β |
| Unravelling the human genome-phenome relationship using phenome-wide association studies. | Bush WS et al. | β | 2016 | β |
| Update on the molecular biology of dyslipidemias. | Ramasamy I | β | 2016 | β |
| Additional mechanisms conferring genetic susceptibility to Alzheimer's disease. | Calero M et al. | β | 2015 | β |
| Aetiological overlap between anxiety and attention deficit hyperactivity symptom dimensions in adolescence. | Michelini G et al. | β | 2015 | β |
| A Hierarchical Factor Model of Executive Functions in Adolescents: Evidence of Gene-Environment Interplay. | Li JJ et al. | β | 2015 | β |
| A metastructural model of mental disorders and pathological personality traits. | Wright AG et al. | β | 2015 | β |
| Annual research review: Infant development, autism, and ADHD--early pathways to emerging disorders. | Johnson MH et al. | β | 2015 | β |
| Childhood IQ and risk of bipolar disorder in adulthood: prospective birth cohort study. | Smith DJ et al. | β | 2015 | β |
| Complex Genetics of Type 2 Diabetes and Effect Size: What have We Learned from Isolated Populations? | Nair AK et al. | β | 2015 | β |
| Connecting Anxiety and Genomic Copy Number Variation: A Genome-Wide Analysis in CD-1 Mice. | BrenndΓΆrfer J et al. | β | 2015 | β |
| Copy number variations play important roles in heredity of common diseases: a novel method to calculate heritability of a polymorphism. | Nagao Y | β | 2015 | β |
| Developmental psychopathology in an era of molecular genetics and neuroimaging: A developmental neurogenetics approach. | Hyde LW | β | 2015 | β |
| Eighty percent of French sport winners in Olympic, World and Europeans competitions have mutations in the hemochromatosis HFE gene. | Hermine O et al. | β | 2015 | β |
| Endophenotypes for Alcohol Use Disorder: An Update on the Field. | Salvatore JE et al. | β | 2015 | β |
| Enhanced Visual Search in Infancy Predicts Emerging Autism Symptoms. | Gliga T et al. | β | 2015 | β |
| Gene-Environment Interplay: Where We Are, Where We Are Going. | Salvatore JE et al. | β | 2015 | β |
| Genetic and environmental components of family history in type 2 diabetes. | Cornelis MC et al. | β | 2015 | β |
| Genetic determinants of depression: recent findings and future directions. | Dunn EC et al. | β | 2015 | β |
| Genetic Heterogeneity in Adolescents' Depressive Symptoms in Response to Victimization. | Gottfredson NC et al. | β | 2015 | β |
| Genetics and intelligence differences: five special findings. | Plomin R et al. | β | 2015 | β |
| Genetics of anxiety disorders: Genetic epidemiological and molecular studies in humans. | Shimada-Sugimoto M et al. | β | 2015 | β |
| Genetics of type 2 diabetes-pitfalls and possibilities. | Prasad RB et al. | β | 2015 | β |
| Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci. | Stafford-Smith M et al. | β | 2015 | β |
| GRIN2B predicts attention problems among disadvantaged children. | Riva V et al. | β | 2015 | β |
| Homogeneous case subgroups increase power in genetic association studies. | Traylor M et al. | β | 2015 | β |
| Identifying genetic risk variants for coronary heart disease in familial hypercholesterolemia: an extreme genetics approach. | Versmissen J et al. | β | 2015 | β |
| Illness progression, recent stress, and morphometry of hippocampal subfields and medial prefrontal cortex in major depression. | Treadway MT et al. | β | 2015 | β |
| Insights into the genetic foundations of human communication. | Graham SA et al. | β | 2015 | β |
| Integrative Analysis of Transcriptomic and Epigenomic Data to Reveal Regulation Patterns for BMD Variation. | Zhang JG et al. | β | 2015 | β |
| Ion channel gene expression predicts survival in glioma patients. | Wang R et al. | β | 2015 | β |
| Is Schizotypy per se a Suitable Endophenotype of Schizophrenia? - Do Not Forget to Distinguish Positive from Negative Facets. | Grant P | β | 2015 | β |
| Mapping asthma-associated variants in admixed populations. | Mersha TB | β | 2015 | β |
| Mapping complex traits as a dynamic system. | Sun L et al. | β | 2015 | β |
| Mixed model with correction for case-control ascertainment increases association power. | Hayeck TJ et al. | β | 2015 | β |
| Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis. | Carey CE et al. | β | 2015 | β |
| Mortality in female and male French Olympians: a 1948-2013 cohort study. | Antero-Jacquemin J et al. | β | 2015 | β |
| Neuron-based heredity and human evolution. | Gash DM et al. | β | 2015 | β |
| New Interview and Observation Measures of the Broader Autism Phenotype: Description of Strategy and Reliability Findings for the Interview Measures. | Parr JR et al. | β | 2015 | β |
| Nuclear factor, erythroid 2-like 2-associated molecular signature predicts lung cancer survival. | Qian Z et al. | β | 2015 | β |
| Polygenic Influence on Educational Attainment: New evidence from The National Longitudinal Study of Adolescent to Adult Health. | Domingue BW et al. | β | 2015 | β |
| Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults. | Salvatore JE et al. | β | 2015 | β |
| Positive attributes in children and reduced risk of future psychopathology. | Vidal-Ribas P et al. | β | 2015 | β |
| Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics. | Soininen P et al. | β | 2015 | β |
| Serotonin and stress coping. | Puglisi-Allegra S et al. | β | 2015 | β |
| Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD. | Stergiakouli E et al. | β | 2015 | β |
| Subjective response as a consideration in the pharmacogenetics of alcoholism treatment. | Roche DJ et al. | β | 2015 | β |
| Target Enrichment Improves Mapping of Complex Traits by Deep Sequencing. | Guo J et al. | β | 2015 | β |
| The association of thyroid peroxidase antibody risk loci with susceptibility to and phenotype of Graves' disease. | KuΕ A et al. | β | 2015 | β |
| The effects of electronic medical record phenotyping details on genetic association studies: HDL-C as a case study. | Dumitrescu L et al. | β | 2015 | β |
| The epidemiology and genetics of binge eating disorder (BED). | Davis C | β | 2015 | β |
| The genetic architecture of pediatric cognitive abilities in the Philadelphia Neurodevelopmental Cohort. | Robinson EB et al. | β | 2015 | β |
| The interface between genetics and psychology: lessons from developmental dyslexia. | Bishop DV | β | 2015 | β |
| The role of schizotypy in the study of the etiology of schizophrenia spectrum disorders. | Barrantes-Vidal N et al. | β | 2015 | β |
| The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review. | Reeve S et al. | β | 2015 | β |
| Thinking positively: The genetics of high intelligence. | Shakeshaft NG et al. | β | 2015 | β |
| Understanding heterogeneity in the effects of birth weight on adult cognition and wages. | Justin Cook C et al. | β | 2015 | β |
| Advances in understanding and treating persecutory delusions: a review. | Freeman D et al. | β | 2014 | β |
| Amygdala reactivity and negative emotionality: divergent correlates of antisocial personality and psychopathy traits in a community sample. | Hyde LW et al. | β | 2014 | β |
| Appetite for prevention: genetics and developmental epidemiology join forces in obesity research. | Belsky DW | β | 2014 | β |
| Are genetic risk factors for psychosis also associated with dimension-specific psychotic experiences in adolescence? | Sieradzka D et al. | β | 2014 | β |
| A review of systems for psychology and psychiatry: adaptive systems, personality psychopathology five (PSY-5), and the DSM-5. | Harkness AR et al. | β | 2014 | β |
| Attentional but not pre-attentive neural measures of auditory discrimination are atypical in children with developmental language disorder. | Kornilov SA et al. | β | 2014 | β |
| Attention-deficit/hyperactivity disorder polygenic risk scores predict attention problems in a population-based sample of children. | Groen-Blokhuis MM et al. | β | 2014 | β |
| Beyond Punnett squares: Student word association and explanations of phenotypic variation through an integrative quantitative genetics unit investigating anthocyanin inheritance and expression in Brassica rapa Fast plants. | Batzli JM et al. | β | 2014 | β |
| Brain galanin system genes interact with life stresses in depression-related phenotypes. | Juhasz G et al. | β | 2014 | β |
| Comparing partial least square approaches in a gene- or region-based association study for multiple quantitative phenotypes. | Yuan Z et al. | β | 2014 | β |
| Developmental imaging genetics: linking dopamine function to adolescent behavior. | Padmanabhan A et al. | β | 2014 | β |
| Disentangling the molecular genetic basis of personality: from monoamines to neuropeptides. | Montag C et al. | β | 2014 | β |
| Dual Linkage of a Locus to Left Ventricular Mass and a Cardiac Gene Co-Expression Network Driven by a Chromosome Domain. | Scott-Boyer MP et al. | β | 2014 | β |
| Either the dorsal hippocampus or the dorsolateral striatum is selectively involved in consolidation of forced swim-induced immobility depending on genetic background. | Colelli V et al. | β | 2014 | β |
| Epistasis and natural selection shape the mutational architecture of complex traits. | Jones AG et al. | β | 2014 | β |
| Evidence for shared genetic risk between ADHD symptoms and reduced mathematics ability: a twin study. | Greven CU et al. | β | 2014 | β |
| From early markers to neuro-developmental mechanisms of autism. | Gliga T et al. | β | 2014 | β |
| From temporal processing to developmental language disorders: mind the gap. | Protopapas A | β | 2014 | β |
| Gene-environment interaction research in psychiatric epidemiology: a framework and implications for study design. | Belsky DW et al. | β | 2014 | β |
| Genetic architecture of cognitive traits. | Le Hellard S et al. | β | 2014 | β |
| Genetic associations with intimate partner violence in a sample of hazardous drinking men in batterer intervention programs. | Stuart GL et al. | β | 2014 | β |
| Genetic basis of delay discounting in frequent gamblers: examination of a priori candidates and exploration of a panel of dopamine-related loci. | Gray JC et al. | β | 2014 | β |
| Genome-wide and gene-based association studies of anxiety disorders in European and African American samples. | Otowa T et al. | β | 2014 | β |
| Genome-wide association study of receptive language ability of 12-year-olds. | Harlaar N et al. | β | 2014 | β |
| Identical genetic influences underpin behavior problems in adolescence and basic traits of personality. | Lewis GJ et al. | β | 2014 | β |
| Identification of loci that cause phenotypic variation in diverse species with the reciprocal hemizygosity test. | Stern DL | β | 2014 | β |
| Influence of single nucleotide polymorphisms on thrombin generation in factor V Leiden heterozygotes. | Segers O et al. | β | 2014 | β |
| Integrating genetics and social science: genetic risk scores. | Belsky DW et al. | β | 2014 | β |
| Laboratory evolution of adenylyl cyclase independent learning in Drosophila and missing heritability. | Cressy M et al. | β | 2014 | β |
| Nature, Nurture, and Expertise. | Plomin R et al. | β | 2014 | β |
| Opportunism: a panacea for implementation of whole-genome sequencing studies in nutrigenomics research? | Ahmadi KR et al. | β | 2014 | β |
| Polygenic risk predicts obesity in both white and black young adults. | Domingue BW et al. | β | 2014 | β |
| Quantitative measurement of odor detection thresholds using an air dilution olfactometer, and association with genetic variants in a sample of diverse ancestry. | Cook GR et al. | β | 2014 | β |
| Quantitative trait analysis of polymorphisms in two bilirubin metabolism enzymes to physiologic bilirubin levels in Chinese newborns. | Zhou Y et al. | β | 2014 | β |
| Subthreshold traits of the broad autistic spectrum are distributed across different subgroups in parents, but not siblings, of probands with autism. | Robel L et al. | β | 2014 | β |
| TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population. | Cook-Sather SD et al. | β | 2014 | β |
| The Duality of Schizotypy: Is it Both Dimensional and Categorical? | Mason OJ | β | 2014 | β |
| The NIMH Research Domain Criteria (RDoC) Project: implications for genetics research. | Simmons JM et al. | β | 2014 | β |
| The potential to predict the course of childhood asthma. | Belsky DW et al. | β | 2014 | β |
| Addictive behaviors and addiction-prone personality traits: associations with a dopamine multilocus genetic profile. | Davis C et al. | β | 2013 | β |
| A genetic deconstruction of neurocognitive traits in schizophrenia and bipolar disorder. | Fernandes CP et al. | β | 2013 | β |
| Aggression and polymorphisms in AR, DAT1, DRD2, and COMT genes in Datoga pastoralists of Tanzania. | Butovskaya ML et al. | β | 2013 | β |
| A powerful latent variable method for detecting and characterizing gene-based gene-gene interaction on multiple quantitative traits. | Li F et al. | β | 2013 | β |
| Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction. | Levran O et al. | β | 2013 | β |
| Bargaining models of depression and evolution of cooperation. | RosenstrΓΆm T | β | 2013 | β |
| Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children. | Kulminski AM et al. | β | 2013 | β |
| Child development and molecular genetics: 14 years later. | Plomin R | β | 2013 | β |
| Development and evaluation of a genetic risk score for obesity. | Belsky DW et al. | β | 2013 | β |
| 'Food addiction' and its association with a dopaminergic multilocus genetic profile. | Davis C et al. | β | 2013 | β |
| Genetics in population health science: strategies and opportunities. | Belsky DW et al. | β | 2013 | β |
| Genetic variants in HHIP are associated with FEV1 in subjects with chronic obstructive pulmonary disease. | Kim WJ et al. | β | 2013 | β |
| Genome-wide association analysis of copy number variation in recurrent depressive disorder. | Rucker JJ et al. | β | 2013 | β |
| Genomics of human health and aging. | Kulminski AM et al. | β | 2013 | β |
| How environment and genes shape the adolescent brain. | Paus T | β | 2013 | β |
| Intrinsic connectivity networks and personality: the temperament dimension harm avoidance moderates functional connectivity in the resting brain. | Markett S et al. | β | 2013 | β |
| Lack of associations of ten candidate coronary heart disease risk genetic variants and subclinical atherosclerosis in four US populations: the Population Architecture using Genomics and Epidemiology (PAGE) study. | Zhang L et al. | β | 2013 | β |
| Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation. | Angata T et al. | β | 2013 | β |
| Network statistics of genetically-driven gene co-expression modules in mouse crosses. | Scott-Boyer MP et al. | β | 2013 | β |
| Overview of Behavioral Genetics Research for Family Researchers. | Samek D et al. | β | 2013 | β |
| Pathological implications of Th1/Th2 cytokine genetic variants in BehΓ§et's disease: Data from a pilot study in a Sicilian population. | Vaccarino L et al. | β | 2013 | β |
| Persecutory ideation and a history of cannabis use. | Freeman D et al. | β | 2013 | β |
| Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: evidence from a 4-decade longitudinal study. | Belsky DW et al. | β | 2013 | β |
| Polygenic risk and the development and course of asthma: an analysis of data from a four-decade longitudinal study. | Belsky DW et al. | β | 2013 | β |
| Structure and function of complex brain networks. | Sporns O | β | 2013 | β |
| The future of genomics for developmentalists. | Plomin R et al. | β | 2013 | β |
| The pharmacology of regenerative medicine. | Christ GJ et al. | β | 2013 | β |
| The Polycystic Ovary Syndrome and recent human evolution. | Corbett S et al. | β | 2013 | β |
| The role of gene-environment correlations and interactions in middle childhood depressive symptoms. | Wilkinson PO et al. | β | 2013 | β |
| Unraveling genetic origin of aging-related traits: evolving concepts. | Kulminski AM | β | 2013 | β |
| A flexible likelihood framework for detecting associations with secondary phenotypes in genetic studies using selected samples: application to sequence data. | Liu DJ et al. | β | 2012 | β |
| A knowledge-based method for association studies on complex diseases. | Nazarian A et al. | β | 2012 | β |
| A latent modeling approach to genotype-phenotype relationships: maternal problem behavior clusters, prenatal smoking, and MAOA genotype. | McGrath LM et al. | β | 2012 | β |
| A latent variable partial least squares path modeling approach to regional association and polygenic effect with applications to a human obesity study. | Xue F et al. | β | 2012 | β |
| Are prenatal ultrasound scans associated with the autism phenotype? Follow-up of a randomised controlled trial. | Stoch YK et al. | β | 2012 | β |
| A unified method for detecting secondary trait associations with rare variants: application to sequence data. | Liu DJ et al. | β | 2012 | β |
| Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors. | Neumann ID et al. | β | 2012 | β |
| Bringing a developmental perspective to anxiety genetics. | McGrath LM et al. | β | 2012 | β |
| Childhood attention-deficit hyperactivity disorder as an extreme of a continuous trait: a quantitative genetic study of 8,500 twin pairs. | Larsson H et al. | β | 2012 | β |
| Discovering the hidden sub-network component in a ranked list of genes or proteins derived from genomic experiments. | GarcΓa-Alonso L et al. | β | 2012 | β |
| Epigenesis for epidemiologists: does evo-devo have implications for population health research and practice? | Davey Smith G | β | 2012 | β |
| Fast identification of biological pathways associated with a quantitative trait using group lasso with overlaps. | Silver M et al. | β | 2012 | β |
| Gene discovery in familial cancer syndromes by exome sequencing: prospects for the elucidation of familial colorectal cancer type X. | Ku CS et al. | β | 2012 | β |
| Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS). | Shi H et al. | β | 2012 | β |
| Genetic variants on chromosome 1q41 influence ocular axial length and high myopia. | Fan Q et al. | β | 2012 | β |
| Genomic research to identify novel pathways in the development of abdominal aortic aneurysm. | Harrison SC et al. | β | 2012 | β |
| Individual differences in holistic processing predict face recognition ability. | Wang R et al. | β | 2012 | β |
| Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis. | Derks EM et al. | β | 2012 | β |
| Meta-analysis of gene-based genome-wide association studies of bone mineral density in Chinese and European subjects. | Cheung CL et al. | β | 2012 | β |
| Next generation sequencing in epigenetics: insights and challenges. | Meaburn E et al. | β | 2012 | β |
| Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study. | Belsky DW et al. | β | 2012 | β |
| Predictors of relapse in a bupropion trial for smoking cessation in recently-abstinent alcoholics: preliminary results using an aggregate genetic risk score. | McGeary JE et al. | β | 2012 | β |
| Psychopathology and the human connectome: toward a transdiagnostic model of risk for mental illness. | Buckholtz JW et al. | β | 2012 | β |
| Quantitative high-throughput metabolomics: a new era in epidemiology and genetics. | Ala-Korpela M et al. | β | 2012 | β |
| Sequencing of high-complexity DNA pools for identification of nucleotide and structural variants in regions associated with complex traits. | Zaboli G et al. | β | 2012 | β |
| Spermatogenic defects in F2 mice between normal mouse strains C3H and C57BL/6 without mutation. | Gotoh H et al. | β | 2012 | β |
| Supporting the generalist genes hypothesis for intellectual ability/disability: the case of SNAP25. | Rizzi TS et al. | β | 2012 | β |
| The (15)N isotope effect as a means for correlating phenotypic alterations and affected pathways in a trait anxiety mouse model. | Filiou MD et al. | β | 2012 | β |
| The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach. | Derringer J et al. | β | 2012 | β |
| The QTN program and the alleles that matter for evolution: all that's gold does not glitter. | Rockman MV | β | 2012 | β |
| The role of phenotype in gene discovery in the whole genome sequencing era. | Almasy L | β | 2012 | β |
| The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review. | Ray LA et al. | β | 2012 | β |
| The role of the catechol-O-methyltransferase (COMT) gene in personality and related psychopathological disorders. | Montag C et al. | β | 2012 | β |
| Unilateral and bilateral expression of a quantitative trait: asymmetry and symmetry in coronal craniosynostosis. | HeuzΓ© Y et al. | β | 2012 | β |
| What is complex about complex disorders? | Mitchell KJ | β | 2012 | β |
| Wrapper-based selection of genetic features in genome-wide association studies through fast matrix operations. | Pahikkala T et al. | β | 2012 | β |
| A longitudinal twin study on the association between inattentive and hyperactive-impulsive ADHD symptoms. | Greven CU et al. | β | 2011 | β |
| Are autistic traits in the general population stable across development? | Whitehouse AJ et al. | β | 2011 | β |
| A systematic review and meta-analysis of the fertility of patients with schizophrenia and their unaffected relatives. | Bundy H et al. | β | 2011 | β |
| Autistic-like traits and their association with mental health problems in two nationwide twin cohorts of children and adults. | LundstrΓΆm S et al. | β | 2011 | β |
| Commentary: Why are children in the same family so different? Non-shared environment three decades later. | Plomin R | β | 2011 | β |
| Dorsolateral prefrontal Ξ³-aminobutyric acid in men predicts individual differences in rash impulsivity. | Boy F et al. | β | 2011 | β |
| Evidence that autistic traits show the same etiology in the general population and at the quantitative extremes (5%, 2.5%, and 1%). | Robinson EB et al. | β | 2011 | β |
| Gene-environment interaction in the etiology of mathematical ability using SNP sets. | Docherty SJ et al. | β | 2011 | β |
| Genetic determinants of plasma triglycerides. | Johansen CT et al. | β | 2011 | β |
| Genetic Overlap between ADHD Symptoms and Reading is largely Driven by Inattentiveness rather than Hyperactivity-Impulsivity. | Greven CU et al. | β | 2011 | β |
| Genetics in liver disease: new concepts. | Zimmer V et al. | β | 2011 | β |
| Genetics of rheumatoid arthritis: GWAS and beyond. | McAllister K et al. | β | 2011 | β |
| Genome wide association studies of abdominal aortic aneurysms-biological insights and potential translation applications. | Harrison SC et al. | β | 2011 | β |
| Higher-order genetic and environmental structure of prevalent forms of child and adolescent psychopathology. | Lahey BB et al. | β | 2011 | β |
| Intellectual property rights in publicly funded biobanks: much ado about nothing? | Pathmasiri S et al. | β | 2011 | β |
| Interaction between susceptibility and environment: examples from the digestive tract. | Rogler G | β | 2011 | β |
| Liver fibrogenesis and genetic factors. | Boursier J et al. | β | 2011 | β |
| Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity. | Nikolova YS et al. | β | 2011 | β |
| Of 508 mice and 40,000 humans. | Dina C | β | 2011 | β |
| Personality Measurement and Assessment in Large Panel Surveys* | Roberts B et al. | β | 2011 | β |
| Personalized medicine can pave the way for the safe use of CBβ receptor antagonists. | Lazary J et al. | β | 2011 | β |
| Perspectives on genome-wide multi-stage family-based association studies. | Van Steen K | β | 2011 | β |
| Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants. | Guey LT et al. | β | 2011 | β |
| Proteomic and metabolomic profiling of a trait anxiety mouse model implicate affected pathways. | Zhang Y et al. | β | 2011 | β |
| Proteomics and metabolomics analysis of a trait anxiety mouse model reveals divergent mitochondrial pathways. | Filiou MD et al. | β | 2011 | β |
| Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood. | Nemoda Z et al. | β | 2011 | β |
| Research review: gene-environment interaction research in youth depression - a systematic review with recommendations for future research. | Dunn EC et al. | β | 2011 | β |
| The clinical implications of mouse models of enhanced anxiety. | Sartori SB et al. | β | 2011 | β |
| The past, present, and future of genetic associations in type 1 diabetes. | Baker PR et al. | β | 2011 | β |
| The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms. | Wagner GP et al. | β | 2011 | β |
| The tryptophan depletion challenge test in medical research: unresolved issues and broader implications for the use of physiological challenges to investigate and categorize disease. | Delgado PL | β | 2011 | β |
| Toward better QSAR/QSPR modeling: simultaneous outlier detection and variable selection using distribution of model features. | Cao D et al. | β | 2011 | β |
| Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan. | Kulminski AM et al. | β | 2011 | β |
| UGT1A1 sequence variants and bilirubin levels in early postnatal life: a quantitative approach. | Hanchard NA et al. | β | 2011 | β |
| A genome-wide association study identifies multiple loci associated with mathematics ability and disability. | Docherty SJ et al. | β | 2010 | β |
| An alternative method of acute lung injury classification for use in observational studies. | Shah CV et al. | β | 2010 | β |
| Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia. | Zhang G et al. | β | 2010 | β |
| Construct validity of the definition of primary graft dysfunction after lung transplantation. | Christie JD et al. | β | 2010 | β |
| Dissection of genetically complex traits with extremely large pools of yeast segregants. | Ehrenreich IM et al. | β | 2010 | β |
| Equine clinical genomics: A clinician's primer. | Brosnahan MM et al. | β | 2010 | β |
| Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. | Johansen CT et al. | β | 2010 | β |
| Extraversion predicts individual differences in face recognition. | Li J et al. | β | 2010 | β |
| Extreme evolutionary disparities seen in positive selection across seven complex diseases. | Corona E et al. | β | 2010 | β |
| Extremes of unexplained variation as a phenotype: an efficient approach for genome-wide association studies of cardiovascular disease. | Lanktree MB et al. | β | 2010 | β |
| Genetics and Intervention Research. | Plomin R et al. | β | 2010 | β |
| Genetics of cholestatic liver disease in 2010. | Karlsen TH et al. | β | 2010 | β |
| Genetic variants and their interactions in the prediction of increased pre-clinical carotid atherosclerosis: the cardiovascular risk in young Finns study. | Okser S et al. | β | 2010 | β |
| Genome-wide association studies and genetic risk assessment of liver diseases. | Krawczyk M et al. | β | 2010 | β |
| Genome-wide association studies in nephrology research. | KΓΆttgen A | β | 2010 | β |
| In search of genes associated with risk for psychopathic tendencies in children: a two-stage genome-wide association study of pooled DNA. | Viding E et al. | β | 2010 | β |
| Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer. | Chari R et al. | β | 2010 | β |
| Linking genes with exercise: where is the cut-off? | Flueck M et al. | β | 2010 | β |
| Neuroimaging creativity: a psychometric view. | Arden R et al. | β | 2010 | β |
| Patients can diagnose too: How continuous self-assessment aids diagnosis of, and recovery from, depression. | Groot PC | β | 2010 | β |
| Phenomics: expanding the role of clinical evaluation in genomic studies. | Lanktree MB et al. | β | 2010 | β |
| Phenomics: the next challenge. | Houle D et al. | β | 2010 | β |
| Quantitative genetics in the era of molecular genetics: learning abilities and disabilities as an example. | Haworth CM et al. | β | 2010 | β |
| Recent advances in the genetics of language impairment. | Newbury DF et al. | β | 2010 | β |
| The origins and evolution of genetic disease risk in modern humans. | Crespi BJ | β | 2010 | β |
| The utility of genome-wide association studies in hepatology. | Karlsen TH et al. | β | 2010 | β |
| Uncovering the roles of rare variants in common disease through whole-genome sequencing. | Cirulli ET et al. | β | 2010 | β |
| Visualizing genetic similarity at the symptom level: the example of learning disabilities. | Davis OS et al. | β | 2010 | β |