Chunk #60 — Methods — Additional Replication through Further Follow-Up Using In Silico Results from the CHARGE Consortium — Meta-analysis of stage 1+2 results with CHARGE data
For the MSRA locus, genotypes for rs7826222 were only available for a subset of the CHARGE samples (N = 8,097). This is due to the fact that this SNP has been renamed to rs545854 in NCBI build 36 and was consequently one of the SNPs omitted from HapMap release 22 and therefore is not present in build 36 imputations based on that release of HapMap. Nonetheless, the effect of rs7826222 in CHARGE was directionally-consistent (P = 0.28), and CHARGE data available in larger sample size (N = 31,372) for two moderately-good proxies (rs1876511 and rs613080, both r2 = 0.76 with rs7826222/rs545854) and both show some support (both had directionally-consistent effect-sizes and P = 0.078) with the other findings.
