in the brain. They found that DOCK3 was expressed at the highest levels in the frontal, temporal, and occipital lobes, whereas SLC9A9 was expressed highest in the medulla and spinal cord (De Silva et al., 2003). Given these data, it is possible that the disruption of one or both of these genes contribute to the behavioral phenotype segregating in this family (De Silva et al., 2003). There are several mechanisms by which this inversion may produce a phenotypic effect, including disruption of a regulatory region, haploinsufficiency of one or both genes, or the creation of a novel or abnormal protein with altered function (De Silva et al., 2003).
