The meta-analysis resulted in 8 independent genome-wide significant SNP associations (linkage disequilibrium [LD] R2<0.1, window size 250 kb) on chromosomes 3, 7, 8, 11, 16, and 17 (Table 1, Supplementary Table S1, and Figure 1). The top SNP and 2 other independent associations were located in CADM2 on chromosome 3 (rs2875907, p=9.38e-17; rs1448602, p=6.55e-11; rs7651996, p=2.37e-09). Other hits were located in ZNF704, SDK1, NCAM1, RABEP2/ATP2A1, and SMG6 (Figure 2). All SNPs combined explained 11% (h2SNP=0.11, SE=0.01) of the individual differences in lifetime cannabis use. Supplementary Figure S1-S3 and Table S2 provide information on results of the individual GWASs (ICC, UK-Biobank, and 23andme).
