There are a number of caveats that should be borne in mind while considering our results obtained at the population level. First, since we chose a DMN subregion atlas, our study aimed at insight into how segregation and integration unfold within this brain phenomenon. However, we do not provide insight into how these observations fit into views of other networks or neural systems. It will be important to examine how network fragmentation approaches may play out in other cortical networks, such as the frontoparietal network. Second, we explored how the group-defined DMN links to the rest of the brain, identifying patterns of organization within this system through their variation across 10,000 individuals. While our analysis highlights the topographic location in which signals within the group-defined DMN possibly carry information about neural processing distributed across the cortex, there is likely to be important information that can be gained by exploring this problem at a more fine-grained level. Recent evidence suggests the existence of parallel interdigitated networks that together make up what is commonly labeled as DMN after averaging across individuals (15).
