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Chunk #22 — Discussion

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Subspecialization within default mode nodes characterized in 10,000 UK Biobank participants.
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Despite the considerable methodological differences between this previous participant level and our population level results, there are nonetheless certain similarities. In particular, the DMN subtype A proposed by Braga and Buckner (15) appears to extend toward more posterior regions of the TPJ (similar to TPJ-2 in our study), more ventromedial prefrontal cortex (vmPFC-1/3 here), and ventral/retrosplenial PCC (PMC-2/4). In contrast, the DMN subtype B appears localized to the anterior TPJs (TPJ-1 here), more dorsomedial prefrontal cortex (dmPFC-1/2/3/4 here), and dorsal PCC (PMC-3 here). These similarities are noteworthy given the diverging methodology in the two studies.