In this study, we genotyped 11 SNPs in the OPRM1 gene. Nine of the 11 makers were in the Hardy-Weinberg Equilibrium (HWE). Two SNPs (rs524731 and rs10485057) showed significant deviation from the HWE, Table 1. When HWE was examined separately for the 3 subject groups, none of the 3 groups was significantly deviated from HWE for rs524731, the P values were 0.182, 0.616 and 0.079 for the NS, Low-ND and High-ND groups respectively. For rs10485057, the HWE deviation was caused largely by the High-ND group, the P values for the NS, Low-ND and High-ND were 0.069, 0.979 and 0.000 respectively. The average scoring rate for the 11 SNPs was 95.6% (94.2–98.7%).
