In TAG [14], the conditional analyses indicated residual association at rs684513 (p = 6.3×10−9), rs9788682 (p = 1.06×10−8), and rs7163730 (p = 1.22×10−8), which attain genome-wide significance. These SNPs are each correlated with locus 2, and much less correlated with locus 3 (r2 = 0.7, 0.55 and 0.56 respectively with rs578776 in HapMap CEU; r2<0.11 with rs588765). It is possible that differences in samples, phenotype definitions, or analysis methods may be contributing to the differences between our strong findings for locus 3 and the three other consortium reports. To further understand the genetic contributions in this region, more work is needed, and not only statistical evidence but also biological evidence will be important.
