Chunk #48 — Discussion

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Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.

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In the ENGAGE study [12], conditioning on the locus 1 SNP rs1051730 identified residual evidence at rs2869046 (p = 4.8×10−5) and rs2036534 (p = 9.1×10−5), neither of which is genome-wide significant. Rs2036534 tags locus 2 (r2 = 0.74 with rs578776 in HapMap CEU) while rs2869046 is only weakly correlated with locus 3 (r2 = 0.46).