We also tested for interactions between the PGS and CERI and cohort (Add Health EUR as the reference group). There were few significant interactions and no consistent patterns in variation for PGS, though the CERI did show considerable variation across cohort (Supplemental Table S4). Finally, we fit complimentary models using a random effects approach, allowing the slopes for the PGS and CERI to vary randomly across cohort. Random slopes for PGS did not consistently improve model fit, though a random slope for the CERI consistently improved model fit (Supplemental Table S5). We compared the parameter estimates from the random effect models to the main analyses and results were largely consistent (Supplemental Table S6).
