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Chunk #35 — Results — Linkage Disequilibrium Score Regression (LDSC)

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A Developmentally-Informative Genome-wide Association Study of Alcohol Use Frequency.
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Univariate and cross-trait LD score regression intercepts, estimates of SNP-based heritability, genetic covariances, and genetic correlations are presented in Table 1. SNP-based heritability for each trait was modest (Adolescence H2SNP = .04, SE=0.04; Early Adulthood H2SNP = .05, SE = 0.05; Adulthood H2SNP = .08, SE = 0.04). Genetic correlations between adolescence and early adulthood (rG = −.27, SE = 0.79), adolescence and adulthood (rG = −.34, SE = 0.65), and early adulthood and adulthood (rG = .75, SE = 0.58) had very wide confidence intervals and were not statistically significant. Notably, all estimates of H2SNP were small, indicating that the genetic correlations reported here account for only a small proportion of the overall relationship between these phenotypes.