5e-8 and p < 1e-5) as the proportion of SNP p-values less than the threshold. The threshold p < 5e-8 represents the common criteria for genome-wide significance (Z. Chen et al. 2021; Risch & Merikangas, 1996), and the threshold p < 1e-5 represents the criteria for a “suggestive” effect (Lander & Kruglyak, 1995). Figure S13 displays a diagram of the simulation analysis model.
