Genomic loci reaching genome-wide significance in the meta-analysis were further targeted with conditional analyses to estimate the number of independent signals. We ran association analyses separately in each of the three cohorts conditioning on our SNP with the lowest p-value, followed by a meta-analysis of the three cohorts. The next signal was identified from the conditional meta-analysis results, and included in the second round of conditional analyses. This process was repeated in an iterative fashion until no residual genome-wide significant signal (p<5E-08) remained.
