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Chunk #25 — Results — Tissue-Specific Expression of PPP3CA Alternatively Spliced Isoforms

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Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease.
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2(B), 427-ATVEAIEADE-436] as compared to CNEX13-15. CNEX13-14 is more concentrated in brain, whereas CNEX13-15 is more concentrated in peripheral tissues (Table 3). CNEX1-2, CNEX1-4, and CNEX9-11 with truncated N-terminus, partial deletion of phosphatase domain, and complete deletion of subunit b binding domain, respectively, are expressed at low levels in brain regions and peripheral tissues (<2%). CNEX3-12 and 1-10, which have completely deleted phosphatase domains, were expressed at very low levels (<0.2%) and only detected in brain (Table 3).