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Chunk #68 — Discussion — Implications and Conclusions

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Behavioral disinhibition: liability for externalizing spectrum disorders and its genetic and environmental relation to response inhibition across adolescence.
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Response inhibition is also emerging as an important executive function related to psychiatric conditions outside the externalizing spectrum, such as schizophrenia (Donohoe, Corvin, & Robertson, 2006; Ross, Heinlein, Zerbe, & Radant, 2005; Thoma, Zoppelt, Wiebel, & Daum, 2007), unipolar depression (Kaiser et al., 2003), obsessive-compulsive disorder (Herrmann, Jacob, Unterecker, & Fallgatter, 2003; Kim, Kim, Yoo, & Kwon, 2007), and borderline personality disorder (Nigg, Silk, Stavro, & Miller, 2005). Thus, continued investigation of the links between response inhibition and an array of psychiatric illnesses may provide new insights into their underlying biological vulnerabilities.