paperKB
coga / coga-kb
Help
Sign in

Chunk #41 — Discussion

Source
Neuronal generator patterns of olfactory event-related brain potentials in schizophrenia.
Embedded
yes

Text

The reduction of N1 sink over lateral temporal lobe sites and P2 source over medial parietal sites in schizophrenia patients was bilateral and not dependent on hemisphere. However, the P2 source and lateral frontotemporal sink, as well as the frontopolar source accompanying N1, were greater over right than left hemisphere sites across both patients and healthy adults. In this regard, brain-damaged patients with lesions to the temporal lobe or orbitofrontal cortex, particularly in the right hemisphere, showed deficits in higher-order odor processing (Jones-Gotman & Zatorre, 1993), and patients with right-sided lesions of the frontal or temporal lobe showed decreased amplitudes of P2 and P3 potentials to odors at parietal sites (Daniels et al., 2001). Positron emission tomography (PET) studies measuring regional cerebral blood flow (rCBF) in healthy adults judging the pleasantness and intensity of odors have provided additional evidence supporting the important role of right orbitofrontal cortex in olfactory processing (Zatorre, Jones-Gotman, & Rouby, 2000). Malaspina et al. (1998) measured rCBF (using SPECTscans) in 6 schizophrenia patients and 7 controls during an odor identification task, and the patients showed hypometabolism