Chunk #23 — Results — Microarray analysis — Within-groups analysis: BP iPSC vs BP neurons and control iPSC vs control neurons

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Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients.

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The ribonuclease DICER1, which is involved in microRNA processing, was significantly higher in BP but not control neurons. Factors involved in ventral neuronal fate such as NKX2-1 and PAX2 were significantly induced in BP, whereas transcripts involved in dorsal fate such as EMX2 (dorsal telencephalon), and HOX genes (HOXA1,6,7) required for positional identity and regional differentiation of the hindbrain were significantly higher in control neurons.