Chunk #6 — Results — The striatal D1/D2 MSNs display a smaller cell body and a shorter dendritic arborization than the two other types of MSNs

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Striatal Neurons Expressing D and D Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice.

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In sham animals, the cell body of dorsal striatum D1/D2 MSNs injected with Lucifer yellow are smaller than those of the D1 and the D2 MSNs: the mean diameter of the D1/D2 MSN perikarya is 12.5 ± 0.4 μm compared to 14.3 ± 0.4 μm for the D1 (P = 0.0094) and to 15.0 ± 0.5 μm for the D2 MSNs (P = 0.0009). The reconstruction of somatodendritic domains of Lucifer yellow-filled MSNs reveals that the total dendritic length of D1/D2 MSNs is also smaller than that of the D1 and the D2 MSNs. The mean total dendritic length for the D1/D2 MSNs is 0.75 ± 0.06 mm compared to 1.48 ± 0.13 mm for D1 (P < 0.0001) and 1.08 ± 0.08 mm for D2 MSNs (P = 0.0296, Fig. 5a). We also noted that the dendritic arborization of the D1 MSNs is significantly longer than that of the D2 MSNs (P = 0.0089). The dendritic arborization of the D1/D2 MSNs is significantly less profuse than that of the D1 and D2 MSNs, as indicated by a smaller number