Mode 7 primarily links bone density measures and cognitive scores to brain structure and dMRI measures. There is extensive literature linking volume and diffusivity measures to cognition, but a relationship between these measures and bone density has not to our knowledge been reported. This link could reflect variations in physical properties of non-interest that are not fully accounted for by de-confounding. However, correlations between low bone density and accelerated cognitive decline have been reported36 including association of bone density with Alzheimer’s disease37.
