While these modes are not guaranteed to reflect biological processes, in practice ICA often produces such interpretability35. Of the nine modes, some reflected dominant physical factors (e.g., body size or heart rate), while others linked rich subsets of non-imaging measures to IDPs. Modes 7-9 are displayed in Fig 7, with modes 7 and 9 discussed in detail below, continuing our focus on the relationship between IDPs and cognitive tests. Modes 1-6 are overviewed in Supplementary Figs 3-7. The relationship of these multivariate associations to potential confounds and variables of interest, including some clinical outcomes, is explored in Supplementary Fig 8. Modes 1,2,4,5,7,8 were strongly associated with aging, whereas 3,6,9 were not.
