We used mtCOJO35 to condition the summary statistics of cannabis use disorder on loci associated with cannabis use at p<0·0015 to adjust for as many SNPs as possible while retaining computational efficiency. Adjusted summary statistics were used to recompute genetic correlations. Because of the high co-occurrence of cannabis use and tobacco smoking, we also did mtCOJO analyses to condition the summary statistics of cannabis use disorder for loci significantly associated with smoking initiation and cigarettes smoked per day36 (p<5·00 × 10−8; excluding 23andMe data, because of restricted access). Moreover, given long-standing interest in the comorbidity of schizophrenia and cannabis misuse, we used mtCOJO to condition the summary statistics of cannabis use disorder on significant schizophrenia loci.37
