In order to understand whether directly-imaged adipose traits are associated with previously-identified loci in a GWAS for fat distribution using anthropometric traits, we performed an association analysis of the 14 previously-published loci for WHR-adjusted-for-BMI for all 4 of our traits in the overall sample and by sex (Table 3) in the results from the GIANT consortium [32]. Overall, we observed associations (defined as p<0.01) for 7/14 of the previously reported loci, most of which were direction-consistent (with the exception of loci associated with SAT, consistent with the fact that SAT and hip are highly correlated traits [r = 0.92 among 2656 individuals from the Family Heart Study]). We observed only one association with VAT at the NISCH-STAB1 locus.
