Chunk #103 — III. Selected Methodological Issues — C. Analyses — 1. Achieving significant genome wide association in single samples vs seeking replication and generalization in multiple samples

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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b) Replicate sample approaches: Here we use an alternative analytic approach that focuses on step-wise assessments. These step wise analyses address the problem of multiple testing by seeking nominally-significant results that can be replicated in several independent samples. We can assess the significance of these replicated, nominally-significant results through use of Monte Carlo methods that correct for multiple comparisons.