Our primary analysis was to determine if any intersecting sub-bins across Asians and African Americans would display evidence of consistent association when comparing heavy versus light smokers, where we defined a consistent association as having the same direction and p value < 0.01 in both populations. Our binning strategy resulted in 100 single sub-bin tests and 67 conditional association tests across the four bins: a total of 167 tests. Because the probability of any particular test resulting in a p-value < 0.01 in both non-European populations by chance would be 0.0001 (=0.01×0.01), results consistently associated in both populations would remain significant after Bonferroni correction (167×0.0001< 0.05).
