Following a systematic literature search to identify VBM and DTI studies on the localization of WM alterations in AUD, we conducted a coordinate-based neuroimaging meta-analysis, which revealed four significant clusters of convergent macro- and microstructural WM changes. The clusters covered parts of the genu and the body of the corpus callosum with extensions to the fornix as well as the anterior and posterior cingulum bundle. Another cluster comprises the right posterior limb of the internal capsule. A similar pattern was observed when conducting the meta-analysis based on DTI studies only. The latter analysis revealed an additional cluster within the posterior parts of the left corpus callosum.
