associated with schizophrenia (Table 2 and Supplementary Data). These extended from low-level molecular and subcellular processes to broad behavioral phenotypes. The most strongly associated gene set constituted the targets of the fragile X mental retardation protein (FMRP)32. FMRP is a neuronal RNA-binding protein that interacts with polyribosomal mRNAs (the 842 target transcripts of this gene set32) and is thought to act by inhibiting translation of target mRNAs, including many transcripts of pre- and postsynaptic proteins. The FMRP target set has been shown to be enriched for rare mutational burden in exome sequencing studies of de novo variation in autism33 and intellectual disability31. In schizophrenia, it has also been shown to be nominally significantly enriched for association signal in sequencing studies8,31 and GWAS5,8, but has only inconsistently been associated in studies of CNV30,34. Here we provide the strongest evidence thus far for enrichment of this gene set in schizophrenia.
