We highlight another five gene sets that are independently associated with schizophrenia. Three of these derive from the Mouse Genome Informatics (MGI) database35 and relate to behavioral and neurophysiological correlates of learning: abnormal behavior (MP:0004924), abnormal nervous system electrophysiology (MP:0002272) and abnormal long-term potentiation (MP:0002207). We note that two of these gene sets (MP:0004924 and MP:0002207) were among the five most enriched of the 134 gene sets tested in a recent schizophrenia CNV analysis30. The remaining two independently associated genes sets were voltage-gated calcium channel complexes36 and the 5-HT2C receptor complex37. The calcium channel finding confirms extensive evidence from common and rare variant studies implicating calcium channel genes in schizophrenia5,8, including a new GWAS locus in CACNA1D identified in our meta-analysis. While there is less convergent evidence in support of the involvement of the 5-HT2C receptor complex in schizophrenia, the fact that we identify independent association for this gene set implicates these genes in schizophrenia pathophysiology and potentially rejuvenates a previous avenue of 5-HT2C ligand therapeutic endeavor in schizophrenia research38. However, we interpret this result with caution given the small
