We report here a GWAS of two alcohol-related traits in a sample of 274,424 MVP participants from five population groups—EA, AA, LA, EAA, and SAA—using two EHR-derived phenotypes: age-adjusted AUDIT-C score and AUD diagnostic codes. In addition to the large number of EAs, the study included large numbers of African-American and Latino-American participants. Trans-population meta-analyses identified 13 independent GWS loci for AUDIT-C and 10 independent GWS loci for AUD. For AUDIT-C, in addition to the loci identified in the SNP-based analyses, there were 31 GWS genes in EAs, 3 in AAs, 1 in LAs, and 2 in EAAs. For AUD, in addition to the loci identified in the SNP analyses, there were 23 GWS genes identified in EAs, 5 in AAs, and 1 in LAs.
