To identify secondary phenotypes associated with AUDIT-C or AUD, we performed a phenome-wide association analysis (PheWAS) of the AUDIT-C and AUD PRS (p value threshold = 1 × 10−7 and all SNPs) in the MVP hold-out sample (Supplementary Data 48, 49). In EAs, the AUDIT-C PRS was significantly associated with an increased risk of alcoholic liver damage, and nominally associated with a decreased risk of hyperglyceridemia. No significant associations were found for AAs. The AUD PRS was significantly associated with an increased risk of tobacco use disorder in both EAs and AAs, and in EAs with multiple psychiatric disorders, including major depression, bipolar disorder, anxiety, and schizophrenia.
