This is the largest and most comprehensive genetic study of MDD. There were 18 759 subjects in the MDD discovery phase, 57 478 subjects in the MDD replication phase and 32 050 subjects in cross-disorder analyses of MDD and BIP. Analyses included the primary phenotype of MDD, three sets of autosomal imputation data (HapMap3, HapMap2 and 1000 Genomes), analysis of chrX, and multiple sub-phenotypes selected based on prior epidemiological and genetic epidemiological studies (Table 2).
