Finally, under the assumptions that MDD is highly polygenic and that power is not optimal,69,70 we conducted risk profile analyses using the MDD discovery phase samples. We split these samples into two sets and used 80% to develop a risk profile to predict case–control status in the remaining 20% of the samples (Supplementary Methods). These analyses showed a modest (R2 = 0.6%) but highly significant (P<10−6) predictive capacity.
