Chunk #22 — The search for gene variants related to alcohol sensitivity (See Table 1) — GABA-related genes

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A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity.

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The potential relevance to alcohol responses of GABRA1 (chromosome 5q34) variants comes from animal knockout, gene expression, and between-strain animal studies (e.g., Hanchar et al., 2005; Loh and Ball, 2000), as well as a human genome-wide association study (GWAS) using single dose oral alcohol (Wilhelmsen et al., 2003). Dick et al. (2006b) reported that SRE-based low LR was related to rs1037715.