Chunk #23 — The search for gene variants related to alcohol sensitivity (See Table 1) — GABA-related genes

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A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity.

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Several animal studies implicated GABRA6 (chromosome 5q34) regarding lower LRs for cerebellar and movement-related effects (Korpi et al., 1993; Sander et al., 1999). Oral alcohol challenges indicated that GABRA6 Pro385Ser related to lower LRs (Hu et al., 2005; Schuckit et al., 1999), especially in combination with L variants of the serotonin transporter gene (5-HTTLPR).