One such model is the selectively bred high and low alcohol-preferring mice (HAP and LAP, respectively). To generate these selected lines, researchers phenotyped mice from a genetically heterogenous foundation stock of HS/Ibg mice (obtained from the Institute of Behavior Genetics at Boulder, CO) for preference of a 10% ethanol (alcohol; v/v) solution over water in a continuous access paradigm (see Oberlin et al., 2011 for a detailed description of these lines). Mice with the highest degree of alcohol preference were bred together and the same was done with the lowest preferers. The offspring of these animals were the first generation of HAP and LAP mice, respectively. As phenotyping and selective breeding continued over generations, the HAP and LAP lines increasingly diverged in alcohol preference and consumption (Matson & Grahame 2013; Oberlin et al. 2011). Eventually, the 10% alcohol solution accounted for nearly all of the daily fluid intake for HAP mice with consumption > 20 g/kg/day of alcohol and blood alcohol concentrations measured ~80–225 mg/dl, 80 mg/dl being equivalent to the legal driving limit in the United States (Matson &
