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Chunk #33 — Results — Application to a meta-analysis of blood lipids combined with a liver expression dataset

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Bayesian test for colocalisation between pairs of genetic association studies using summary statistics.
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Table 2 lists the 14 colocalised loci (15 genes) that were not reported by Teslovich et al. (or in Global Lipids Genetics Consortium [24] for the gene NYNRIN), but for which our method finds strong support for colocalisation (PP4 >75%). Figure S7 shows the LocusZoom plots for these colocalisation results. Eleven of these 15 genes are strong candidates for involvement in lipid metabolism and/or have been previously suggested as candidate genes: SDC1, TGOLN2, INHBB, UBXN2B, VLDLR, VIM, CYP26A1, OGFOD1, HP, HPR, PPARA. See Text S2 for a brief overview of the function of these genes. Four others genes have a less obvious link: CMTM6, C6orf106, CUX2, ENSG00000259359.