One of these genes, ANGPTL3 is noteworthy. Examining this locus (Figure S6), it is clear that the pattern of association p-values is consistent between LDL and ANGPTL3 expression. However, the extent of LD is strong, with 98 strongly associated variants. In such a situation, there is uncertainty as to whether the data support a shared causal variant for both traits, or two distincts variants for eQTL/LDL. Because the data are consistent with both scenarios, the choice of prior becomes determinant. Accordingly, PP4 drops from 91% to 49% if one uses instead of .
