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Chunk #24 — Results — GCTA Heritability and Weighted Genome-Wide Association Analysis of BMI

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The National Longitudinal Study of Adolescent to Adult Health (Add Health) sibling pairs genome-wide data.
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(p=5×10−8) while the blue horizontal line represents a threshold of p=5×10−5. Table 4 displays the 39 SNP associations achievingp< 5.0×10−5 ordered by genomic location. We chose a threshold of p< 5.0×10−5 as a reasonable, albeit arbitrary, threshold for association signals that warrants potential follow-up as other studies have done (e.g. see Carty et al., 2012). In the table, we report the SNP marker name, chromosome, base pair location, and the nearest gene and where that SNP is located relative to that gene. We also report the allele conferring risk (increasing BMI units), the frequency of that allele and the other allele present in the data (reported as forward strand). Finally, we report the results of the analysis including the linear mixed model coefficient (corresponding 95% confidence interval), the unweighted p-value, the weight applied to that SNP marker and the corresponding weighted p-value. In this analysis, the linear mixed model coefficient may be interpreted as the additive effect of the risk allele on body mass index in units of kg/m2. For example, the C allele of SNP rs1421085 (FTO gene) is associated with a 0.27 kg/m2 increase in BMI. Overall, the list of 39 SNPs include some marker pairs that are