allele on body mass index in units of kg/m2. For example, the C allele of SNP rs1421085 (FTO gene) is associated with a 0.27 kg/m2 increase in BMI. Overall, the list of 39 SNPs include some marker pairs that are likely in high linkage disequilibrium (LD) from the same genic region. Additionally, the influence of the weighting scheme can clearly be seen in the table. Using weights in this way allows for strongly significant markers to sift to the top even when down-weighted. There are 6 SNP markers that were down-weighted, yet still achieved a genome-wide suggestive level. However, the remaining 30 SNP markers were up-weighted. Therefore, this is largely a list of SNPs that have been pushed towards the top of the association signals as they are SNPs with prior information indicating evidence of association with BMI (GIANT consortium) and achieved at least nominal significance in the Add Health sample. A notable signal includes the highly replicable FTO gene region (chromosome 16) providing evidence that the Add Health sibling pairs sample is an informative genetic dataset for future use.
