Lastly, we used stratified LD Score regression40 to test for the enrichment of SNPs associated with histone marks in 10 tissue or cell types (Supplementary Note). Central nervous system tissues are the most enriched, accounting for 44% (SE = 3%) of the heritability while comprising only 15% of the SNPs (Supplementary Fig. 11a and Supplementary Table 22). Immune/hematopoietic tissues are also significantly enriched. While a role for the immune system in modulating risk tolerance is plausible given prior evidence of its involvement in several neuropsychiatric disorders36,37, future work is needed to confirm this result and to uncover specific pathways that might be involved.
