The Gene Network and the DEPICT tissue enrichment analyses also both separately point to enrichment of the prefrontal cortex and the basal ganglia (Fig. 3b and Supplementary Tables 18, 20, and 21). The cortical and subcortical regions highlighted by DEPICT include some of the major components of the cortical-basal ganglia circuit, which is known as the reward system in human and non-human primates and is critically involved in learning, motivation, and decision-making, notably under risk and uncertainty38,39. We caution, however, that our results do not point exclusively to the reward system.
