Effect sizes from several previous case-control studies (see Table S10) demonstrated a similar widespread pattern of CT differences (see Figure 3B). Correlation analysis suggested that most of the case-control brain difference patterns were correlated with one another, with the correlation coefficient ranging from 0.32 to 0.77. Notably, with the exception of MDD, these case-control brain difference patterns were significantly correlated with the spatial pattern of PC1 with the correlation coefficients ranging from −0.34 to −0.66. The negative signs reflected the fact that the standard loadings of the Combined-PC1 were positive and most regional effect sizes from case-control comparisons were negative. The correlation coefficients and p values of the correlation analysis are shown in Table S11. The sensitivity analysis indicated that alcohol dependence effects observed in ENIGMA-Addiction and UKB remained correlated with the Combined-PC1 derived from the data without controls used in the group comparisons (r=-0.65, p-spin<0.001; r=-0.61, p-spin<0.001).
