Depressed subjects with co-morbid SUDs are at increased risk for suicide (Niciu et al. 2009). Interestingly, ketamine decreases suicidality in high-risk populations (Price et al. 2009; DiazGranados et al. 2010b), including in the emergency setting (Larkin et al. 2011), but it remains to be seen if ketamine or other glutamatergic modulators have anti-suicidal properties in this high risk population.
